NSC-311068
NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1[1].
Product Specifications
CAS Number
[73768-68-0]
UNSPSC
12352005
Target
TET Protein
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-311068.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
[O-][N+](C1=CC=C(C([N+]([O-])=O)=C1)SC2=CC=NC=N2)=O
Molecular Formula
C10H6N4O4S
Molecular Weight
278.24
References & Citations
[1]Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8 (1) :2099.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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