Charybdotoxin

<strong>Charybdotoxin</strong> <strong>Catalog number:</strong> MDP0612 <strong>CAS Number: </strong>137813-35-5 <strong>Sequence: </strong>Pyr-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser (Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 4295.6 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Garcia ML, Knaus HG, Munujos P, Slaughter RS, Kaczorowski GJ. Charybdotoxin and its effects on potassium channels Am J Physiol. 1995 Jul;269(1 Pt 1):C1-10. 2: Miller C. The charybdotoxin family of K+ channel-blocking peptides Neuron. 1995 Jul;15(1):5-10. 3: Liu X, Tao J, Zhang S, Lan W, Yao Y, Wang C, Xue H, Ji Y, Li G, Cao C. Development of charybdotoxin Q18F variant as a selective peptide blocker of neuronal BK(α + β4) channel for the treatment of epileptic seizures Protein Sci. 2022 Dec;31(12):e4506. 4: Tenenholz TC, Klenk KC, Matteson DR, Blaustein MP, Weber DJ. Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides Rev Physiol Biochem Pharmacol. 2000;140:135-85. 5: Moldenhauer H, Díaz-Franulic I, Poblete H, Naranjo D. Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states Elife. 2019 Jul 4;8:e46170. 6: Khabiri M, Nikouee A, Cwiklik L, Grissmer S, Ettrich R. Charybdotoxin unbinding from the mKv1.3 potassium channel: a combined computational and experimental study J Phys Chem B. 2011 Oct 6;115(39):11490-500. 7: Sollini M, Frieden M, Bény JL. Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells Br J Pharmacol. 2002 Aug;136(8):1201-9. 8: Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG. Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels J Biol Chem. 2000 Jan 14;275(2):1201-8. 9: Nikouee A, Khabiri M, Grissmer S, Ettrich R. Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison J Phys Chem B. 2012 May 3;116(17):5132-40. <a href="https://pubmed.ncbi.nlm.nih.gov/12466245">10: Bychkov R, Burnham MP, Richards GR, Edwards G, Weston AH, Félétou M, Vanhoutte PM. Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF Br J Pharmacol. 2002 Dec;137(8):1346-54. </a> <br><strong>Products Related to Charybdotoxin can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>