L-Aspartic acid

L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions[1][2][3].

Product Specifications

CAS Number

[56-84-8]

UNSPSC

12352211

Hazard Statement

H302

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/L-Aspartic_acid.html

Purity

99.87

Solubility

1M NaOH : 100 mg/mL (ultrasonic; adjust pH to 12 with NaOH) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@H](C(O)=O)CC(O)=O

Molecular Formula

C4H7NO4

Molecular Weight

133.10

Precautions

H302

References & Citations

[1]Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73 (3) :1206-11.|[2]Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly (L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23 (4) :397-406.|[3]Su G, et al. Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. Redox Biol. 2024 May;71:103112.