D-Leucine-d10
Product Specifications
UNSPSC Description
D-Leucine-d10 is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
Target Antigen
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease
Purity
99.80
Solubility
H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[C@](N)([2H])C(O)=O
Molecular Weight
141.23
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
No Development Reported
CAS Number
271247-12-2
Available Sizes
Curated Selection
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