Maleimido-tri (ethylene glycol) -propionic acid
Maleimido-tri (ethylene glycol) -propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Maleimido-tri (ethylene glycol) -propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1]. Maleimido-tri (ethylene glycol) -propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product Specifications
CAS Number
[518044-40-1]
Product Name Alternative
Mal-PEG3-acid
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/maleimido-tri-ethylene-glycol-propionic-acid.html
Purity
99.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCOCCOCCOCCN1C(C=CC1=O)=O
Molecular Formula
C13H19NO7
Molecular Weight
301.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhou D, et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29 (7) :943-947.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers
Available Sizes
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