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Maleimido-tri(ethylene glycol)-propionic acid

Product Specifications

Product Name Alternative

Mal-PEG3-acid

UNSPSC Description

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1]. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Target Antigen

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related;PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/maleimido-tri-ethylene-glycol-propionic-acid.html

Purity

99.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CCOCCOCCOCCN1C(C=CC1=O)=O

Molecular Weight

301.29

References & Citations

[1]Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-130426/Maleimido-tri-ethylene-glycol-propionic-acid-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-130426/Maleimido-tri-ethylene-glycol-propionic-acid-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

518044-40-1

Available Sizes

Curated Selection

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