Bimatoprost grenod

Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO) -donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma[1][2].

Product Specifications

CAS Number

[1194396-71-8]

Product Name Alternative

NCX 470

UNSPSC

12352005

Hazard Statement

H225-H361

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bimatoprost-grenod.html

Purity

98.34

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O[C@@H](CCC1=CC=CC=C1)/C=C/[C@@H]2[C@@H](C/C=C\CCCC(NCC)=O)[C@@H](O)C[C@H]2O)CCCCCO[N+]([O-])=O

Molecular Formula

C31H46N2O8

Molecular Weight

574.71

Precautions

P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501

References & Citations

[1]Impagnatiello F, et al. Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma. Br J Pharmacol. 2019 Apr;176 (8) :1079-1089.|[2]Impagnatiello F, et al. Intraocular Pressure-Lowering Activity of NCX 470, a Novel Nitric Oxide-Donating Bimatoprost in Preclinical Models. Invest Ophthalmol Vis Sci. 2015 Oct;56 (11) :6558-64.