Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Salinomycin

Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells[1][2][3].

Product Specifications

CAS Number

53003-10-4

Product Name Alternative

Procoxacin

UNSPSC

12352005

Hazard Statement

H300

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; Mitophagy; Parasite; Wnt; β-catenin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Salinomycin.html

Purity

99.74

Solubility

DMSO : ≥ 36.7 mg/mL

Smiles

[H][C@]1([C@](C)(CC2)O[C@]32[C@H](O)C=C[C@]4(O[C@]([H])([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O)=O)([H])CC[C@@H]5C)=O)[C@@H](C)C[C@H]4C)O3)CC[C@@](CC)(O)[C@H](C)O1

Molecular Formula

C42H70O11

Molecular Weight

751.00

Precautions

H300

References & Citations

[1]Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108 (32) :13253-7.|[2]Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222 (2) :139-45.|[3]Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7 (12) : e50638.|[4]Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8 (7) :578-82.|[5]Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14 (2) :e0211916.|[6]Naujokat C, et al. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol. 2012;2012:950658.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Coccidia

Citation 01

ACS Infect Dis. 2021 Aug 13;7 (8) :2390-2401.|Acta Biomater. 2022 Oct 15:152:380-392.|Adv Sci (Weinh) . 2025 Feb 8:e2415229.|Adv Sci (Weinh) . 2025 Sep 9:e13476.|Anal Chem. 2023 Apr 11;95 (14) :6191.|Biochim Biophys Acta Mol Cell Res. 2025 May 11:119989.|Biomed J. 2020 Aug;43 (4) :368-374.|bioRxiv. 2020 Jun.|bioRxiv. 2023 Jan 17.|bioRxiv. 2023 Jun 25.|bioRxiv. 2024 September 07.|bioRxiv. 2024 September 18.|Biosens Bioelectron. 2024 Jul 1:255:116245.|Cancers. 2020 Aug 5;12 (8) :2176.|Cell Biosci. 2021 Aug 4;11 (1) :156.|Cell Commun Signal. 2018 Nov 23;16 (1) :89.|Cell Death Dis. 2023 Mar 11;14 (3) :193.|Cell Oncol (Dordr) . 2024 Dec;47 (6) :2201-2215.|Chemosphere. 2024 Jul 3:142758.|EMBO Mol Med. 2019 Oct;11 (10) :e9930.|Eur J Med Chem. 2024 Oct 5:276:116701.|Eur J Pharmacol. 2025 Jul 5:998:177533.|Hepatol Commun. 2025 May 16;9 (6) :e0706.|Int J Mol Med. 2019 Oct;44 (4) :1289-1298.|Int J Mol Sci. 2019 Jun 12;20 (12) :2861.|Int J Mol Sci. 2023 Mar 21;24 (6) :5939.|Int J Nanomedicine. 2020 Sep 15;15:6839-6854.|J Bioenerg Biomembr. 2021 Oct;53 (5) :513-523.|J Control Release. 2020 Oct 10;326:387-395.|Mol Med. 2025 Jan 22;31 (1) :19.|Nanoscale. 2024 Nov 7;16 (43) :20131-20146.|Norwegian University of Science and Technology. Department of Clinical and Molecular Medicine. 2021 Oct.|Oncol Rep. 2018 Aug;40 (2) :877-886.|Pharmacol Res. 2020 May;155:104751.|RSC Adv. 2021 Nov 2;11 (56) :35331-35341.|Talanta. 2025 Apr 10:293:128128.|Viruses. 2022 Aug 6;14 (8) :1734.|AAPS PharmSciTech. 2024 Sep 7;25 (7) :211.|Cell Rep. 2025 Jul 22;44 (7) :115922.|Eur J Med Chem. 2024 Oct 5:276:116701.|Exp Ther Med. 2020 Mar;19 (3) :1835-1843.|Int J Pharm. 2023 Mar 25:635:122779.|Nat Commun. 2025 Jul 18;16 (1) :6621.|SSRN. 2024 Nov 12.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

ZNF709 Human Gene Knockout Kit (CRISPR)
KN415319 1 Kit

ZNF709 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
WHSC2 (NELFA) Rabbit Polyclonal Antibody
TA365435 100 µL

WHSC2 (NELFA) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
SPDEF (NM_012391) Human Recombinant Protein
TP305688L 1 mg

SPDEF (NM_012391) Human Recombinant Protein

Sign In for Pricing
View Details
IGSF5 Human Gene Knockout Kit (CRISPR)
KN420223 1 Kit

IGSF5 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Human JPT1 activation kit by CRISPRa
GA109611 1 Kit

Human JPT1 activation kit by CRISPRa

Sign In for Pricing
View Details
Involucrin (SY5), CF488A conjugate, 0.1mg/mL
BNC880678-500 1x 500 µL

Involucrin (SY5), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details