DSP-4 (hydrochloride)

DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons[1][2].

Product Specifications

CAS Number

[40616-75-9]

Product Name Alternative

Neurotoxin DSP 4 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301, H311, H315, H319, H331, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dsp-4-hydrochloride.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

CCN(CCCl)CC1=CC=CC=C1Br.[H]Cl

Molecular Formula

C11H16BrCl2N

Molecular Weight

313.06

Precautions

H301, H311, H315, H319, H331, H335

References & Citations

[1]Hormigo S, et al. The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats. Front Neural Circuits. 2012 Jun 28;6:41.|[2]Jaim-Etcheverry G, et al. DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 1980 Apr 28;188 (2) :513-23.