QM31

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].

Product Specifications

CAS Number

[937735-00-7]

Product Name Alternative

SVT016426

UNSPSC

12352005

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/qm31.html

Concentration

10mM

Purity

95.00

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C(C1)N(CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(CN(CCC4=CC=C(Cl)C=C4Cl)C1=O)=O)N(CC(N)=O)CCC5=CC=C(Cl)C=C5Cl

Molecular Formula

C39H38Cl4N4O4

Molecular Weight

768.56

References & Citations

[1]Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14 (2) :182-90.|[2]Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9 (10) :e110979.|[3]Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6 (11) :833-43.