MCC-DM1
MCC-DM1 is a agent-Linker Conjugates for ADC such as Anti-CD22-MCC-DM1. MCC-DM1 can be detected in rat and human plasma, feces, and other tissues[1][2].
Product Specifications
CAS Number
1100692-14-5
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcc-dm1.html
Purity
99.52
Solubility
DMSO : 190 mg/mL (ultrasonic)
Smiles
C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCSC5C(N(C(C5)=O)CC6CCC(CC6)C(N)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
Molecular Formula
C47H64ClN5O13S
Molecular Weight
974.55
References & Citations
[1]Manu Lopus, et al. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307 (2) :113-8.|[2]Liu Y, et al. LC-MS/MS method for the simultaneous determination of Lys-MCC-DM1, MCC-DM1 and DM1 as potential intracellular catabolites of the antibody-drug conjugate trastuzumab emtansine (T-DM1) . J Pharm Biomed Anal. 2017 Apr 15;137:170-177.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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