Tocainide (hydrochloride)

Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].

Product Specifications

CAS Number

[71395-14-7]

UNSPSC

12352005

Hazard Statement

H302

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tocainide-hydrochloride.html

Purity

99.49

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

CC(N)C(NC1=C(C)C=CC=C1C)=O.[H]Cl

Molecular Formula

C11H17ClN2O

Molecular Weight

228.72

Precautions

H302

References & Citations

[1]Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3 (6) :316-23.|[2]De Luca A, et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64 (4) :932-45.