GGTI-286 (TFA)
GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276. GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2].
Product Specifications
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ggti-286-tfa.html
Purity
92.45
Solubility
10 mM in DMSO
Smiles
CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.OC(C(F)(F)F)=O
Molecular Formula
C25H32F3N3O5S
Molecular Weight
543.60
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD44 Standard (DF1485), CF680 conjugate, 0.1mg/mL
IgA Secretory Component (SC05), CF740 conjugate, 0.1mg/mL
CD45RO (190-2F2.5), CF640R conjugate, 0.1mg/mL
TCF4 (Transcription Factor 4) (TCF4/1705), CF740 conjugate, 0.1mg/mL
