Human LIF Protein

Leukemia Inhibitory Factor (LIF) belongs to the IL-6 superfamily of cytokines. LIF is expressed in a number of tissues and cell types. The LIF receptor is a heterodimer comprised of LIF-R (gp190) and gp130, a common signal transducer for IL-6-type cytokines. Depending on cell type and context, LIF/LIF-R can activate Erk, PI3K, and Jak1/Stat1/3 pathways. LIF has a diverse array of biological activities. Murine embryonic stem cells are dependent on LIF for pluripotency and self-renewal in vitro. Exercise- induced LIF secretion in muscle induces myoblast proliferation, suggesting that LIF may play a role in exercise-induced muscle hypertrophy. LIF also negatively regulates Th2 and Th17 cell differentiation.

Measured in a cell proliferation assay using TF -1. The ED50 for this effect is typically 0.137 ng/mL. The specific activity of recombinant Human LIF is approximately >7.30 x 106 IU/mg

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the　buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.