RN112 rabbit pAb

This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Membrane ; Multi-pass membrane protein . Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus . Nucleus, nuclear body . Nucleus, nucleoplasm . Endosome . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Cell junction, synapse, postsynaptic density . Perikaryon . Cell projection, neuron projection . Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. .