Cabazitaxel

Cabazitaxel is a second generation semisynthetic taxane derived from 10-deacetylbaccatin with potent anticancer activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Cabazitaxel is more potent than docetaxel (Cat. No. 2232) in P-glycoprotein-expressing cell lines with in vitro acquired resistance to taxanes or other chemotherapeutic agents.