MALT1 Inhibitor, MI-2

MALT1 inhibitor MI-2 is a potent inhibitor of the paracaspase MALT1 (Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) (IC₅₀ = 5.84 μM). MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.