TAS-120

TAS-120 is a novel, potent and highly selective FGFR inhibitor that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations. It blocks the phosphorylation of FGFRs and impedes downstream signaling pathways in cells. TAS-120 prevents the proliferation of human cancer cell lines with FGFR gene abnormalities but does not alter the growth of cell lines with wild-type FGFR.