COMT-IN-2
COMT-IN-2 (compund 9) is the potent COMT inhibitor, showing selective inhibition of brain (IC50=24 nM) and liver (IC50=81 nM) MB-COMT compared to the liver S-COMT (IC50=620 nM) isoform[1].
Product Specifications
UNSPSC
12352005
Target
COMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/comt-in-2.html
Smiles
O=C1C=CN(C=C1O)C2=CC(C)=C(C=C2)C
Molecular Formula
C13H13NO2
Molecular Weight
215.25
References & Citations
[1]Benfeito S, et al. Discovery of a Potent, Selective, and Blood-Brain Barrier Permeable Non-nitrocatechol Inhibitor of Catechol-O-methyltransferase. J Med Chem. 2024 Oct 24;67 (20) :18384-18399.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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