PF-670462
PF-670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other kinases. Inhibits PER protein nuclear translocation (EC₅₀ = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
Product Specifications
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months
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