MCB613

MCB-613 is a small-molecule steroid coactivators SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs. MCB-613 can super-stimulate SRCs’ transcriptional activity and increase SRCs’ interactions with other coactivators and markedly induce ER stress coupled to the generation of reactive oxygen species (ROS)