PD-166866

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) (IC₅₀ = 55 nM). It has no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. Displays antiproliferative and anti-angiogenic activities.