KX-392 dihydrochloride

KX-392 is a potent oral non-ATP competitive inhibitor of Src kinase and tubulin polymerization. KX2-391 shows steep dose-response curves against Huh7 (GI₅₀ = 9 nM), PLC/PRF/5 (GI₅₀ = 13 nM), Hep3B (GI₅₀ = 26 nM), and HepG2 (GI₅₀ = 60 nM), four hepatic cell cancer (HCC) cell lines.