C-DIM 12

C-DIM 12 activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NF-kB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells. Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).