Concanamycin A

Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase. It displays > 2000-fold selectivity over other H+-ATPases (IC₅₀ values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H⁺-ATPases and porcine P-type Na⁺,K⁺-ATPase respectively). Concanamycin A blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.