FPL64176
FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM[1][2].
Product Specifications
CAS Number
120934-96-5
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fpl64176.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)NC(C)=C1C(C2=CC=CC=C2CC3=CC=CC=C3)=O)OC
Molecular Formula
C22H21NO3
Molecular Weight
347.41
References & Citations
[1]Zheng W, Rampe D, Triggle DJ. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol Pharmacol. 1991 Nov;40 (5) :734-41.|[2]Baxter AJ, Dixon J, Ince F, Manners CN, Teague SJ. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl) benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J Med Chem.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![PAK4 (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 6C1]](https://cdn.genprice.uk/products/937/68dd189c061270361e8fc6a1/imageurl/am20217pu-n.webp)
AM20217PU-N 100 µg
PAK4 (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 6C1]
Sign In for Pricing
View Details 
13341ES96 96 Tests
Hieff NGS™ Fast-Pace DNA Cyclization Kit for MGI
Sign In for Pricing
View Details 
TRC-T775085-50MG 50 mg
1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-9-iodo-nonane
Sign In for Pricing
View Details ![5-dR6G [5-Carboxy-4,7-dichlororhodamine 6G]](https://cdn.genprice.uk/products/271/7362087/imageurl/300-aat.webp)