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PROTAC STING Degrader-1

PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway with a DC50 of 3.2 μM. PROTAC STING Degrader-1 exerts high anti-inflammatory efficacy. PROTAC STING Degrader-1 can be used to study diseases such as acute kidney injury and inflammatory bowel diseases (IBDs). (Pink: STING ligand ; Blue: CRBN ligand (HY-10984) ; Black: linker (HY-W015883) )[2][3].

Product Specifications

CAS Number

2762552-74-7

UNSPSC

12352005

Target

PROTACs; STING

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/protac-sting-degrader-1.html

Purity

98.26

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)/C=C/C(NC4=CC=C(NC(C5=CC=C([N+]([O-])=O)O5)=O)C=C4)=O

Molecular Formula

C34H33N7O10

Molecular Weight

699.67

References & Citations

[1]Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65 (9) :6593-6611.|[2]Rongxiang Ma, et al., Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury, European Journal of Medicinal Chemistry, Volume 290, 2025, 117539, ISSN 0223-5234.|[3]Shuai Xu, et al., PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING-NLRP3 axis, International Immunopharmacology, Volume 141, 2024, 112990, ISSN 1567-5769.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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