MSC-2530818

MSC-2530818 is a potent, selective CDK8 Inhibitor (IC₅₀ = 2.6 nM). It displays potent inhibition of phospho-STAT1SER727, an established biomarker of CDK8 activity. MSC2530818 demonstrates potent inhibition of WNT-dependent transcription in human cancer cell lines that have constitutively activated WNT signaling.