Ensartinib

Ensartinib (X-396), is a potent, small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Ensartinib has been active in animal models of non-small cell lung cancer (NSCLC) and neuroblastoma. Also, ensartinib has shown activity in models with ALK mutations that confer resistance to other small molecule ALK inhibitors.