CYC-116

CYC116 is a potent inhibitor of Aurora A and B with Ki value of 8 nM and 9.2 nM, respectively. It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 displays broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC₅₀ value of 0.54 µM (range = 0.09 – 1.6 µM).