Aclacinomycin A hydrochloride

Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.