Clamikalant (sodium)

Clamikalant sodium (HMR 1098) is an ATP-sensitive potassium (KATP) channel blocker. Clamikalant sodium can be used for the research of arrhythmia[1].

Product Specifications

CAS Number

[261717-22-0]

Product Name Alternative

HMR 1098

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/clamikalant-sodium.html

Concentration

10mM

Purity

98.27

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([N-]CCC1=CC=C(OC)C(S(=O)(NC(NC)=S)=O)=C1)C2=CC(Cl)=CC=C2OC.[Na+]

Molecular Formula

C19H21ClN3NaO5S2

Molecular Weight

493.96

References & Citations

[1]Garrett J Gross, et al. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET) -induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol. 2013 Jun;59:20-9.|[2]Hai-yan Zhou, et al. Improved myocardial function with supplement of levosimendan to Celsior solution. J Cardiovasc Pharmacol. 2014 Sep;64 (3) :256-65.|[3]Xiaohui Zhang, et al. Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis. Int J Mol Med. 2016 Sep;38 (3) :758-66.