Iadademstat (dihydrochloride)
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K) -specific demethylase 1A (KDM1A/LSD1) inhibitor.
Product Specifications
CAS Number
1431303-72-8
Product Name Alternative
ORY-1001 (dihydrochloride) ; RG6016 (dihydrochloride) ; RO 7051790 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ORY-1001_trans_.html
Purity
99.98
Solubility
DMSO : 0.69 mg/mL (ultrasonic; warming) |H2O : 57.75 mg/mL (ultrasonic; warming)
Smiles
N[C@@H]1CC[C@@H](N[C@H]2[C@H](C3=CC=CC=C3)C2)CC1.[H]Cl.[H]Cl
Molecular Formula
C15H24Cl2N2
Molecular Weight
303.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Maes T, et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics. 2015;7 (4) :609-26. doi: 10.2217/epi.15.9.|[2]Tamara Maes, et al. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. Cancer Cell. 2018 Mar 12;33 (3) :495-511.e12.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
KDM1/LSD1
Citation 01
Cell Biosci. 2022 Aug 30;12 (1) :140|EMBO Mol Med. 2025 Aug 29.|J Appl Toxicol. 2023 Nov;43 (11) :1748-1760.|J Med Chem. 2024 Nov 14;67 (21) :19874-19888.|J Med Chem. 2025 May 8;68 (9) :9260-9278.|Oncogene. 2021 Apr;40 (15) :2711-2724.|bioRxiv. 2025 Oct 15.
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