Iadademstat (dihydrochloride)

Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K) -specific demethylase 1A (KDM1A/LSD1) inhibitor.

Product Specifications

CAS Number

[1431303-72-8]

Product Name Alternative

ORY-1001 (dihydrochloride) ; RG6016 (dihydrochloride) ; RO 7051790 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ORY-1001_trans_.html

Purity

99.98

Solubility

DMSO : 0.69 mg/mL (ultrasonic; warming) |H2O : 57.75 mg/mL (ultrasonic; warming)

Smiles

N[C@@H]1CC[C@@H](N[C@H]2[C@H](C3=CC=CC=C3)C2)CC1.[H]Cl.[H]Cl

Molecular Formula

C15H24Cl2N2

Molecular Weight

303.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Maes T, et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics. 2015;7 (4) :609-26. doi: 10.2217/epi.15.9.|[2]Tamara Maes, et al. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. Cancer Cell. 2018 Mar 12;33 (3) :495-511.e12.