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TY-52156

TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4. TY-52156 has been shown to suppress FTY720-induced S1P3receptor-mediated coronary flow in isolated perfused rat hearts. TY-52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.

Product Specifications

Shipping Conditions

Gel Pack

Storage Conditions

-20°C

Shelf Life

36 months

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