Calcicludine

<strong>Calcicludine</strong> <strong>Catalog number:</strong> MDP0680 <strong>CAS Number: </strong>258279-04-8 <strong>Sequence: </strong>Trp-Gln-Pro-Pro-Trp-Tyr-Cys-Lys-Glu-Pro-Val-Arg-Ile-Gly-Ser-Cys-Lys-Lys-Gln-Phe-Ser-Ser-Phe-Tyr-Phe-Lys-Trp-Thr-Ala-Lys-Lys-Cys-Leu-Pro-Phe-Leu-Phe-Ser-Gly-Cys-Gly-Gly-Asn-Ala-Asn-Arg-Phe-Gln-Thr-Ile-Gly-Glu-Cys-Arg-Lys-Lys-Cys-Leu-Gly-Lys (Disulfide bonds between Cys7-Cys57, Cys16-Cys40, and Cys32-Cys53) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 6980 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Wang X, Du L, Peterson BZ. Calcicludine binding to the outer pore of L-type calcium channels is allosterically coupled to dihydropyridine binding Biochemistry. 2007 Jun 26;46(25):7590-8. 2: Schweitz H, Heurteaux C, Bois P, Moinier D, Romey G, Lazdunski M. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):878-82. 3: Stotz SC, Spaetgens RL, Zamponi GW. Block of voltage-dependent calcium channel by the green mamba toxin calcicludine J Membr Biol. 2000 Mar 15;174(2):157-65. 4: Nishio H, Katoh E, Yamazaki T, Inui T, Nishiuchi Y, Kimura T. Structure-activity relationships of calcicludine and dendrotoxin-I, homologous peptides acting on different targets, calcium and potassium channels Biochem Biophys Res Commun. 1999 Aug 27;262(2):319-21. 5: Gilquin B, Lecoq A, Desné F, Guenneugues M, Zinn-Justin S, Ménez A. Conformational and functional variability supported by the BPTI fold: solution structure of the Ca2+ channel blocker calcicludine Proteins. 1999 Mar 1;34(4):520-32. 6: Taguchi K, Shiina M, Shibata K, Utsunomiya I, Miyatake T. Spontaneous muscle action potentials are blocked by N-type and P/Q-calcium channels blockers in the rat spinal cord-muscle co-culture system Brain Res. 2005 Feb 9;1034(1-2):62-70. 7: Ashenafi S, Fuente A, Criado JM, Riolobos AS, Heredia M, Yajeya J. Beta-Amyloid peptide25-35 depresses excitatory synaptic transmission in the rat basolateral amygdala "in vitro" Neurobiol Aging. 2005 Apr;26(4):419-28. 8: Santos-Torres J, Fuente A, Criado JM, Riolobos AS, Heredia M, Yajeya J. Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum J Neurosci Res. 2007 Feb 15;85(3):634-48. 9: Li Z, Wang X, Gao G, Qu D, Yu B, Huang C, Elmslie KS, Peterson BZ. A single amino acid change in Ca(v)1.2 channels eliminates the permeation and gating differences between Ca(2+) and Ba(2+) J Membr Biol. 2010 Feb;233(1-3):23-33. <a href="https://pubmed.ncbi.nlm.nih.gov/12787339">10: Todorov S, Pozzoli C, Zamfirova R, Poli E. Prejunctional modulation of non-adrenergic non-cholinergic (NANC) inhibitory responses in the isolated guinea-pig gastric fundus Neurogastroenterol Motil. 2003 Jun;15(3):299-306. </a> <br><strong>Products Related to Calcicludine can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>