H4R antagonist 1
H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC50 of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R[1].
Product Specifications
CAS Number
1429375-54-1
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/H4R_antagonist_1.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CNC(C1)CN1C2=NC3=NC=C(Br)C=C3N4C2=NN=N4
Molecular Formula
C11H11BrN8
Molecular Weight
335.16
References & Citations
[1]Ko K, et al. Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis. J Med Chem. 2018 Apr 12;61 (7) :2949-2961.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC401680-500 1x 500 µL
CD45RA (Leukocyte Marker) (K4B5), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
L-1500-1 1 mL
Crude Limulus polyphemus Lectin (Horseshoe Crab) -LPA-
Sign In for Pricing
View Details 
PKSM040987-01 10 µg
Recombinant Mouse COL18A1/Endostatin Protein (His Tag)
Sign In for Pricing
View Details PKSM040987-02 50 µg
Recombinant Mouse COL18A1/Endostatin Protein (His Tag)
Sign In for Pricing
View Details