H4R antagonist 1
H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC50 of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R[1].
Product Specifications
CAS Number
1429375-54-1
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/H4R_antagonist_1.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CNC(C1)CN1C2=NC3=NC=C(Br)C=C3N4C2=NN=N4
Molecular Formula
C11H11BrN8
Molecular Weight
335.16
References & Citations
[1]Ko K, et al. Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis. J Med Chem. 2018 Apr 12;61 (7) :2949-2961.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
Available Sizes
Frequently Asked Questions
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