H4R antagonist 1

H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC50 of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R[1].

Product Specifications

CAS Number

[1429375-54-1]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/H4R_antagonist_1.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CNC(C1)CN1C2=NC3=NC=C(Br)C=C3N4C2=NN=N4

Molecular Formula

C11H11BrN8

Molecular Weight

335.16

References & Citations

[1]Ko K, et al. Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis. J Med Chem. 2018 Apr 12;61 (7) :2949-2961.