Fasiglifam (TAK-875)

Fasiglifam (TAK-875) is a potent and selective agonist of GPR40 with EC₅₀ of 14 nM, 400-fold more potent than oleic acid. TAK-875 displays potent plasma glucose-lowering action and insulinotropic action during an oral glucose tolerance test in female Wistar fatty rats with impaired glucose tolerance.