MK-0941

MK-0941 is selective, allosteric glucokinase activator (GKA) that activates glucokinase (hexokinase subtype IV) with greater selectivity than over different hexokinase isoforms. MK-0941 shows decrease in mean fasting plasma glucose in healthy participants by 30 mg/dL. It displays greater effect in type 2 diabetic patients by lowering the fasting plasma glucose by 100 mg/dL.