PF-06463922
PF-06463922 is a potent, selective, brain-penetrant, and high affinity ALK (Anaplastic lymphoma kinase) and ROS1 (c-Ros oncogene 1) inhibitor displaying >100-fold selectivity for ROS1 over panel of 204 other kinases. It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). It inhibits proliferation of BaF3 cells containing Crizotinib resistant ROS1 mutation in vitro.
Product Specifications
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months
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C2548-38M 100 Tests
CD137 (CD137 Antigen, CDw137, 4-1BB, 4-1BB Ligand Receptor, ILA, MGC2172, T cell Antigen 4-1BB Homolog, T cell Antigen ILA, Tumor Necrosis Factor Receptor Superfamily Member 9, TNFRSF9) (PE) discontinued
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