N-Oxalylglycine

N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell-permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC₅₀s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC₅₀ values of 2.1 and 5.6 μM, respectively.