Ro 18-5364
Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.
Product Specifications
CAS Number
101387-98-8
UNSPSC
12352005
Target
Na+/K+ ATPase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ro-18-5364.html
Smiles
O=C1C(C)(C)C2=C(C=C3NC(S(CC4=NC=CC(OC)=C4C)=O)=NC3=C2)C1(C)C
Molecular Formula
C22H25N3O3S
Molecular Weight
411.52
References & Citations
[1]Ro 18‐5364, a potent new inhibitor of the gastric (H++ K+) ‐ATPase
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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