NSC-59984
NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC₅₀ of NSC-59984 in most cancer cells is significantly lower than those of normal cells, with EC₅₀ of 8.38 μM for p53- HCT116 cells. NSC-59984 induces p73-dependent cell apoptosis in cancer in vivo.
Product Specifications
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months
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