Homoharringtonine

Homoharringtonine (Omacetaxine mepesuccinate; HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

Product Specifications

CAS Number

[26833-87-4]

Product Name Alternative

Omacetaxine mepesuccinate; HHT

UNSPSC

12352005

Hazard Statement

H300

Target

STAT

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Homoharringtonine.html

Purity

99.96

Solubility

DMSO : ≥ 50 mg/mL|H2O : 1.4 mg/mL (ultrasonic)

Smiles

[H][C@@]12[C@](CCC3)(C=C(OC)[C@]2(OC([C@](CCCC(O)(C)C)(O)CC(OC)=O)=O)[H])N3CCC4=CC5=C(OCO5)C=C14

Molecular Formula

C29H39NO9

Molecular Weight

545.62

Precautions

H300

References & Citations

[1]Cao W, et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 2015 Jul 13;5:8477|[2]Yakhni M, et al. Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein abundance. Am J Cancer Res. 2019 May 1;9 (5) :1043-1060.