HEI3090
Product Specifications
UNSPSC Description
HEI3090 is a P2X7R activator. HEI3090 stimulates dendritic cells expressing P2X7R to produce IL-18, which subsequently promotes Natural Killer cells and CD4 T cells within tumors to produce IFN-γ, leading to a sustained antitumor response. HEI3090 can be used to enhance the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC)[1].
Target Antigen
IFNAR; Interleukin Related; P2X Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation;Membrane Transporter/Ion Channel
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hei3090.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=NC=C(C=C1)NC(N2[C@@H](CCC2=O)C(NCC3=C(C=C(C=C3)Cl)Cl)=O)=O
Molecular Weight
441.70
References & Citations
[1]Douguet L, et al. A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy. Nat Commun. 2021 Jan 28;12(1):653.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164426/HEI3090-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164426/HEI3090-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2377167-56-9
Available Sizes
Curated Selection
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