AGI-6780
AGI-6780 is a potent, selective inhibitor of mutant Isocitrate dehydrogenase 2 (IDH2) (IC₅₀ = 23 nM). It binds allosterically at the dimer interface of mutant IDH2-R140Q, inhibiting 2-hydroxyglutarate (2-HG) formation in human glioblastoma U87 and TF-1 cells expressing IDH2-R140Q with IC₅₀ values of 11 and 18 nM, respectively.
Product Specifications
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months
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