AZD-1981

AZD-1981 is a potent and selective antagonist of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2) with an IC₅₀ value of 4 nM; blocks functional responses in eosinophils, Th2 cells and basophils. It exhibits similar potency irrespective of the cell type, DP2 agonist or species used.