HBX-41108

HBX-41108 is a potent inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). HBX-41108 treatment stabilizes p53, activates the transcription of a p53 target gene without inducing genotoxic stress, and inhibits cancer cell growth. Also induces p53-dependent apoptosis in p53 wild type and isogenic cancer cell lines.